Currents within the Drugstore Knowledge and LearningAsma El-Magboub, Ian S
Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Biological goals and you may pharmacology out-of curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin ‘s the major element of brand new reddish dye regarding turmeric, an Indian liven that is obtained from the brand new rhizome of one’s tropical bush Curcuma longa, and that belongs to the Zingiberaceae family unit members. In this section, i discuss the pharmacological issues away from curcumin and speak about the new unit basics for these products. I following feedback the fresh confirmed and you may prospective scientific uses away from curcumin. Curcumin known typically as a healing representative, but their system out of Sano brides step is actually detailed. The fresh pharmacological ramifications of curcumin be seemingly the consequence of good synergism out-of channels off weakened biochemical affairs with numerous physical aim inside interrelated signaling paths. These plans is nutrients including cyclooxygenase, lipoxygenase and you will healthy protein kinases, and you will transcription situations particularly NF-?B, STAT and Nrf2. Modulation ones particles influences downstream affectors that produce the newest antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial items away from curcumin. These consequences was in fact checked within the clinical trials out of curcumin getting pain and you will inflammatory disease, cancer tumors, Alzheimer state, cardio problems, and you may all forms of diabetes. The new examples have used changeable amounts away from curcuminwith more frequencies and you can period, toward standard achievement you to high doses regarding curcumin from the number of g are required to obtain therapeutic outcomes. Find out more
Curcumin: Synthesis, Growing Role into the Serious pain Management and you will Fitness Ramifications
Book Part Samples of bush-derived pharmaceuticals having become the desire away from continued and you will great lookup and you will development desire has, up to now, become a little scarce. Immediately after several years, the past 20 years was in fact characterized by a beneficial 100-bend rise in how many scientific blogs blogged a-year that is actually away from value to the accessibility curcumin within the biomedicine. Read more
Structure, synthesis and you will physical affairs away from curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many potential pharmacological outcomes that can possess healing software in a lot of condition claims, as the chatted about in more detail in the previous part. Yet not, the possibility systematic efficacy out of curcumin is bound of the their physicochemical attributes from terrible h2o solubility and you can instability, hence result in reduced bioavailability. Prodrugs out-of curcumin offer a means to upgrade of biopharmaceutical and pharmacokinetic features, and will ensure it is exploitation of the pharmacological effects of curcumin. Within this part, i very first review the fresh new physicochemical and you can pharmacokinetics regarding curcumin. We after that determine the appearance of curcumin prodrugs having enhanced h2o solubility and enhanced chemical substances balances which are translated returning to totally free curcumin up on bioactivation for the vivo. We focus on latest success in this field, having a focus on the construction, synthesis and you may research regarding prodrugs based on promoieties plus amino acids, efas, nucleic acids, dicarboxylic acids, and you will polymeric information such hyaluronic acid and you may polyethylene glycol. Which section gets the reason behind optimisation of one’s physicochemical and you will biopharmaceutical qualities and physiological situations away from curcumin prodrugs, towards the goal using ones curcumin derivatives in clinical software. Find out more